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KMID : 1123920120260040446
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 4 p.446 ~ p.454
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Study on the Immune Modulatory Activity of Seokjahaeki-tang Using Atopic Dermatitis Animal Models
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Lee Byung-Woong
Kim Seon-Bin
Song Hyang-Hee
Ji Joong-Gu
Park Ji-Won
Kim Dong-Hee
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Abstract
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In order to evaluate the efficacy of SHT against atopic dermatitis (AD), various immune related cytokines as well as histological comparison were performed in animal models, and the results are described. Clinical skin index of the SHT treated group decreased significantly in weeks 11 and 13, compared to the control group. Also, CD4+ immune cell ratio in the dorsal skin was significantly decreased to 69%, and both epidermal and dermal skin thickness was decreased. Serum IL-4, IL-5, IL-6, IL-13, and TNF-α, which are all important markers of inflammation, were decreased to 64%, 44%, 87%, 48%, and 45%, respectively. The expression of histamine, a chemical transmitter increasingly released during the progression of inflammation, was significantly decreased to 47%. The production of IgE immunoglobulin was significantly decreased to 16% compared to the control group. In conclusion, SHT pacifies the activation of T cells, leading to suppression of both Th2 cytokine overexpression and infiltration of immune cells into skin. As a result, relative thinning of both epidermis and dermis were observed. With the results obtained from in vitro studies, the immune modulatory effect of SHT in AD animal models was experimentally demonstrated. This study should provide solid information to construct EBM and for clinical practice.
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KEYWORD
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Atopic dermatitis(AD), Seokjagaeki-tang, Animal model, Cytokines, Immune cell, Clinical skin index
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